JTE-607 Dihydrochloride
Product Specifications
CAS Number
188791-09-5
Target
TNF-alpha
Applications
Apoptosis
Smiles
Cl.Cl.CCOC (=O) C (CC1=CC=CC=C1) NC (=O) C2=CC (=C (OCCN3CCN (C) CC3) C (=C2O) Cl) Cl
Molecular Formula
C25H31Cl2N3O5.2ClH
Additionnal Information
JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF) -alpha, interleukin (IL) -1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.
Storage Conditions
3 years -20°C powder
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