What is the catalog number for JTE-607 Dihydrochloride?

The catalog number for JTE-607 Dihydrochloride is E0314-25mg.

What sizes are available for JTE-607 Dihydrochloride?

JTE-607 Dihydrochloride is available in the following size(s): 25 mg.

Is JTE-607 Dihydrochloride in stock?

JTE-607 Dihydrochloride is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures JTE-607 Dihydrochloride?

JTE-607 Dihydrochloride is manufactured by Bimake.

What is the estimated delivery time for JTE-607 Dihydrochloride?

Estimated delivery time for JTE-607 Dihydrochloride is approximately 15 business day(s), depending on your location.

JTE-607 Dihydrochloride

Product Specifications

CAS Number

188791-09-5

Target

TNF-alpha

Applications

Apoptosis

Smiles

Cl.Cl.CCOC (=O) C (CC1=CC=CC=C1) NC (=O) C2=CC (=C (OCCN3CCN (C) CC3) C (=C2O) Cl) Cl

Molecular Formula

C25H31Cl2N3O5.2ClH

Additionnal Information

JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF) -alpha, interleukin (IL) -1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.