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Indirubin-3′-oxime

Product Specifications

CAS Number

667463-82-3

Synonyms

IDR3O, I3O

Target

GSK-3

Applications

PI3K/Akt/mTOR

Smiles

O\N=C1\C (NC2=CC=CC=C12) =C/3C (=O) NC4=CC=CC=C34

Molecular Formula

C16H11N3O2

Additionnal Information

Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.

Storage Conditions

3 years -20°C powder

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