ML318

ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].

Product Specifications

CAS Number

[1610516-67-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ml318.html

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC(C1=CC=C(F)C=C1)C2=NC(C(F)(F)F)=CC=C2

Molecular Formula

C14H8F4N2

Molecular Weight

280.22

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9 (7) :1536-44.