CDK8-IN-11

CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer[1].

Product Specifications

CAS Number

[2839338-28-0]

UNSPSC

12352005

Target

CDK; Wnt; β-catenin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk8-in-11.html

Purity

98.20

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=C(N)N=C3)C=C2

Molecular Formula

C19H15F3N4O2

Molecular Weight

388.34

References & Citations

[1]Yao Yao Yan, et al. Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy. J Med Chem. 2022 Sep 20.