(R) - (+) -HA-966

(R) - (+) -HA-966 ((+) -HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R) - (+) -HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R) - (+) -HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3].

Product Specifications

CAS Number

[123931-04-4]

Product Name Alternative

(+) -HA-966

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-plus-ha-966.html

Purity

98.85

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1N(O)CC[C@H]1N

Molecular Formula

C4H8N2O2

Molecular Weight

116.12

References & Citations

[1]Hutson PH, et al. R- (+) -HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103 (4) :2037-44.|[2]Witkin JM, et al. Discriminative stimulus effects of R- (+) -3-amino-1-hydroxypyrrolid-2-one, [ (+) -HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275 (3) :1267-73.|[3]Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+) -HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125 (8) :1641-50.