PAR4 antagonist 1
Product Specifications
UNSPSC Description
PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC50 of 1.8 nM. PAR4 antagonist 1 has an IC50 of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research[1].
Target Antigen
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
COC1=NC2=CC(C)=CC(C3=NC4=C(C5=C(C(F)=C4)O[C@H](C5)COC(NC6=CN=C(N=C6)C)=O)S3)=C2N=C1
Molecular Weight
532.55
References & Citations
[1]Zhang X, et al. Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis. J Med Chem. 2024 Feb 22.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163341/PAR4-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163341/
Clinical Information
No Development Reported
CAS Number
2173201-65-3
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