EP4 receptor agonist 2

EP4 receptor agonist 2 (compound 31) a potent EP4 receptor agonist with an EC50 value of 0.8 nM; Ki values of >100000, 38000, 3.1 nM for EP2, EP3, EP4 respectively[1].

Product Specifications

CAS Number

[493035-81-7]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ep4-receptor-agonist-2.html

Concentration

21.28 mM * 100 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC1=C(C=CC(Cl)=C1)C2=CC(C(O)/C=C/[C@@H]3N(C(CC3)=O)CCCCCCC(O)=O)=CC=C2

Molecular Formula

C27H32ClNO4

Molecular Weight

470.00

Precautions

H225, H319

References & Citations

[1]Elworthy TR, et al. Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett. 2004 Apr 5;14 (7) :1655-9.