Anti-Histone H4 tetra acetyl Antibody
Histone H4 is one of the core components of the nucleosome, the basic building block of chromatin. Acetylation of histones is linked to a number of specific processes including transcriptional regulation and genomic organization.
Product Specifications
Host
Rabbit
Species Reactivity
Human
Immunogen
Peptide containing the amino terminal region of Tetrahymena histone variant hv1 acetylated at multiple lysines.
Clonality
Polyclonal
Isotype
IgG
Type
Polyclonal Antibodies
Applications
WB
Concentration
1 μg/μL
Purity
Purified
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Specificity
The immunogen has a high degree of homology to histone H4, so the antibody primarily recognizes tetra-acetylated histone H4, secondarily recognizes tri-acetylated forms of histone H4. Faint recognition of multiply acetylated histone H2A is observed.
Applications Notes
The sequence of the immunogen from Tetrahymena hv1 has a high degree of homology to histone H4 in higher organisms. This modification is conserved from yeast to human and a wide range of reactivity is expected.
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
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