INCA-6

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT (P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling[1][2][3].

Product Specifications

CAS Number

[3519-82-2]

Product Name Alternative

Triptycene-1,4-quinone

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Nuclear Factor of activated T Cells (NFAT)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/inca-6.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 2.86 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=CC(C2=C1C3C4=C(C2C5=C3C=CC=C5)C=CC=C4)=O

Molecular Formula

C20H12O2

Molecular Weight

284.31

Precautions

H315, H319, H320

References & Citations

[1]Ling Xiao, et al. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 2008 Sep 26;103 (7) :733-42.|[2]Miho Shiratori, et al. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem. 2010 Aug;114 (3) :810-9.|[3]Anand Mohan Prasad, et al. Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H173-80.|[4]Colin A Bretz, et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci. 2013 Oct 25;54 (10) :7020-7.