Presatovir

Presatovir (GS-5806) is an orally bioavailable RSV fusion inhibitor with a mean EC50 value of 0.43 nM[1].

Product Specifications

CAS Number

[1353625-73-6]

Product Name Alternative

GS-5806

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

RSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Presatovir.html

Purity

99.91

Solubility

DMSO : 6 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(C=C(Cl)C=C1)=C1NS(C)(=O)=O)N(CCCC2)[C@@H]2C3=NN4C(N=C(N5CC[C@H](N)C5)C(C)=C4)=C3

Molecular Formula

C24H30ClN7O3S

Molecular Weight

532.06

Precautions

H315, H319, H320

References & Citations

[1]Mackman RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58 (4) :1630-1643.|[2]Samuel D, et al. GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein. Antimicrob Agents Chemother. 2015 Nov;59 (11) :7109-12.