TRUPCR® Factor V Leiden Mutation Testing Kit (G1691A)
• CE-IVD • Rapid and extremely accurate test. • Being based on allelic discrimination, the kit is a more reliable and highly reproducible assay. • Higher sensitivity and specificity. • Easy workflow & compatible with Applied Biosystems 7300 / 7500 Real-Time PCR System, AriaMx Real-Time PCR System, CFX ConnectTM / CFX96TM / Dx Real-Time PCR Detection System, QuantStudioTM 3 and 5 Real-Time PCR System, Rotor-Gene Q, StepOneTM / StepOnePlusTM Real-Time PCR System.
Product Specifications
Applications Notes
Factor V Leiden is a blood clotting disorder. Factor V is a protein that is needed for blood to clot properly. Factor V Leiden is caused by a change (mutation) in the gene for this protein. The Factor V Leiden protein is harder to regulate than the normal Factor V protein. This makes blood clots more likely to form, a condition called thrombophilia. The TRUPCR® Factor V Leiden Mutation Testing Kit amplifies and detects the target sequence using allele-specific fluorophore-labelled probes. The target sequence is a single nucleotide guanine/adenine polymorphism in site 1691 (G1691A) . Presence of wild-type allele (G1691G) is detected in the HEX fluorescent channel and mutant allele (A1691A) in the FAM fluorescent channel. In case of heterozygous genotype (G1691A) a signal is detected in both channels. The Factor V mutation testing kit contains ready to use master mix and takes advantage of the “hot start” technology, minimising non-specific reactions and assuring maximum sensitivity.
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