What is the catalog number for TRUPCR® CXCR4 Mutation Detection Kit?

The catalog number for TRUPCR® CXCR4 Mutation Detection Kit is 3B1426.

What sizes are available for TRUPCR® CXCR4 Mutation Detection Kit?

TRUPCR® CXCR4 Mutation Detection Kit is available in the following size(s): 96 Reactions.

Is TRUPCR® CXCR4 Mutation Detection Kit in stock?

TRUPCR® CXCR4 Mutation Detection Kit is currently made to order / not held in immediate stock. Contact us for lead time.

TRUPCR® CXCR4 Mutation Detection Kit

• CE-IVD • Detection of CXCR4 (S338X) mutation with differentiation of c.1013C>G and c.1013C>A nucleotide change • The kit allows highly sensitive and specific diagnosis of CXCR4 Mutation in single run. • The kit offers sensitivity to detect as low as 0.5% allele for both c.1013C>G and c.1013C>A. • All inclusive kit: The Assay includes all the PCR components including PCR Pre-mix / mastermix for optimized results. • Positive control is included in the kit for reliable results

Product Specifications

Applications Notes

The TRUPCR®CXCR4 Mutations Detection Kit is an in vitro diagnostic test intended for the qualitative detection of S338X mutation (c.1013C>G and c.1013C>A, NM_003467.3) in C-X-C motif chemokine receptor 4 (CXCR4) gene from human genomic DNA, extracted from whole blood/bone marrow/FFPE tissue. CXCR4 mutations are common in Waldenstrom’s Macroglobulinemia as well as other lymphomas and are associated with clinical resistance to ibrutinib affecting the treatment decision. The TRUPCR® CXCR4 Mutations Detection Kit is based on allele specific amplification and is achieved by ARMS PCR. The kit is designed to selectively amplify mutant specific sequences in samples that contain a mixture of wild-type and mutated DNA. The detection of mutations is achieved in multiplex reactions using fluorescent probes labeled with FAM, HEX and TEXAS RED. The TRUPCR® CXCR4 Mutations Detection Kit is a three tube assay which helps pinpoint the exact point mutation leading to S338X change.