InVivoMAb Anti-Mouse CD3E Antibody (145-2C11)

145-2C11 is highly effective at inducing T-cell depletion in vivo. In BALB/c mice, administration of 145-2C11 resulted in a marked reduction of circulating T cells, even at very low doses. A single injection of just 1 μg was sufficient to significantly diminish T-cell levels, while higher doses of 20 μg and 100 μg produced even more profound and extensive depletion. These properties make 145-2C11 a powerful experimental tool for modulating T-cell responses and studying immune regulation in murine models.

Product Specifications

Accession Number

P07766

Host

Hamster

Target

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E

Clonality

Monoclonal

Applications

FCM, ICC, IHC, IP, T cell stimulation (Reported), T cell depletion (Reported), WB

Purification

Protein A/G purified from cell culture supernatant.

Stability

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks) . Store at -20°C 12 months. Store at -80°C long term.