(+) -EMD 57033

(+) -EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+) -EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].

Product Specifications

CAS Number

[147527-31-9]

UNSPSC

12352005

Hazard Statement

H302, H319, H335, H373

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plus-emd-57033.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCCC2=C1C=CC(C3=NNC(SC3C)=O)=C2)C4=CC=C(OC)C(OC)=C4

Molecular Formula

C22H23N3O4S

Molecular Weight

425.50

Precautions

H302, H319, H335, H373

References & Citations

[1]Wang X, et al. Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033. J Biol Chem. 2001 Jul 6;276 (27) :25456-66. |[2]Ochala J, et al. EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation. Pflugers Arch. 2010 Feb;459 (3) :475-83. |[3]Hgashiyama A, et al. Effects of EMD 57033 on contraction and relaxation in isolated rabbit hearts. Circulation. 1995 Nov 15;92 (10) :3094-104. |[4]Senzaki H, et al. Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033. Circulation. 2000 Mar 7;101 (9) :1040-8.