Fmoc-Lys (Pal-Glu-OtBu) -OH

Fmoc-Lys (Pal-Glu-OtBu) -OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Lys (Pal-Glu-OtBu) -OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Product Specifications

CAS Number

[1491158-62-3]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-lys-pal-glu-otbu-oh.html

Purity

99.93

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCCCC(N[C@H](C(OC(C)(C)C)=O)CCC(NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)=O)=O

Molecular Formula

C46H69N3O8

Molecular Weight

792.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.