[Arg15, Asp16, 25, Pro18, 21, 23, Val22, Ile24]-Beta-Amyloid-Protein (15-25)

The undecapeptide RDLPFFPVPID (iAβ11) has a similar degree of hydrophobicity as the native amyloid β-peptide (Aβ), but with a low propensity to adopt a β-sheet conformation. It is therefore called anti-β-sheet peptide or β-sheet inhibitor. iAβ11 binds to Aβ, inhibits Aβ fibril formation and partially disaggregates preformed fibrils in vitro. This anti-β-sheet peptide may serve as a starting point to design inhibitors of amyloidogenesis in vivo.