[Des-Leu9]-Kinetensin

Des-Leu-kinetensin, also called histamine-releasing peptide (HRP), was originally isolated from incubates of mammalian albumins with acid proteases, but is also generated by stimulated rat mast cells in the presence of BSA. HRP is able to release histamine from isolated mast cells and to increase cutaneous vascular permeability. Furthermore, the peptide is chemotactic to human and rat neutrophils.