Rno-miR-421-5p miRNA Agomir

This synthetic miRNA is based on the mature miRNA sequence. The antisense strand of the agomir has 2 phosphorothioates at the 5' end, 4 phosphorothioates, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. It exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

Agomir is chemically-modified double-strand miRNA mimics which can mimic mature endogenous miRNAs after transfection into cells. They can up-regulate the endogenous miRNA activity by utilizing the natural miRNA machinery. Our miRNA agomir is designed to mimic mature miRNAs, and chemically modified to increase their stability and activity.