Aselizumab
Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma[1][2].
Product Specifications
CAS Number
395639-53-9
Product Name Alternative
HuDreg-55
UNSPSC
12352203
Target
P-selectin
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aselizumab.html
Purity
99.76
Solubility
10 mM in DMSO
Smiles
[Aselizumab]
Molecular Weight
(144.74 kDa)
References & Citations
[1]Seekamp A, et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med. 2004 Oct;32 (10) :2021-8. |[2]Rahman I, et al. L-selectin regulates human neutrophil transendothelial migration. J Cell Sci. 2021 Feb 8;134 (3) :jcs250340. |[3]Co MS, et al. Properties and pharmacokinetics of two humanized antibodies specific for L-selectin. Immunotechnology. 1999 Mar;4 (3-4) :253-66.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
31612126 3x 1.0µg DNA
NDUFA10 CRISPRa sgRNA lentivector (set of three targets)(Rat)
Sign In for Pricing
View Details 
MBS1233438 Inquire
Recombinant Desulfovibrio vulgaris subsp. vulgaris UPF0059 membrane protein Dvul_0455 (Dvul_0455)
Sign In for Pricing
View Details EVV13501 100 μg
Recombinant Monkeypox virus/MPXV B6R/SL-159 Protein, C-His
Sign In for Pricing
View Details GTR10439612 96 Well
Rabbit Dolichyl diphosphooligosaccharide protein glycosyltransferase 48 kDa subunit (DDOST) ELISA kit
Sign In for Pricing
View Details S5329-13-HRP 100 µL
Solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (sodium-potassium-chloride cotransporter isoform 2, BSC1, Bumetanide-sensitive sodium- (potassium) -chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, MGC48843, NKCC2, Solute carrier family 12 member 1) (HRP)
Sign In for Pricing
View Details