Hsa-miR-449a miRNA Antagomir

Synthetic miRNA Antagomir is used to inhibit the activity of target hsa-miR-449a mRNA.

Product Specifications

Reactivity

Source

Synthetic

Form

Lyophilized powder

Components

This synthetic miRNA is based on the mature miRNA sequence. The strand of the antagomir has 2 phosphorothioates at the 5' end, 4 phosphorothioates, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. Stability of miRNA antagomir appears to be significantly higher than miRNA inhibitors. It exhibits enhanced cellular uptake, stability and regulatory activity and is recommended for miRNA functional studies in vitro and in vivo.

Storage Conditions

Shipped at 4 °C. Store at -20 °C for one year. Avoid freeze-thaw cycles after reconstitution.

Specificity

Antagomir is chemically-modified single-strand miRNA inhibitor functioning by blocking miRNA regulation of target gene expression efficiently. They are synthesized to reduce the ability of endogenous miRNAs to silence target mRNA transcripts. They can down-regulate the corresponding endogenous miRNAs. Our miRNA antagomir is single-strand miRNA inhibitor carrying the chemically modifications functioning by blocking miRNA regulation of target gene expression efficiently.