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(S, R, S) -AHPC-Me-12- ((4-Bromobutyl) amino) dodecanamide

Selected Variant

HY-168290

Size: 1 Each

(S, R, S) -AHPC-Me-12- ((4-Bromobutyl) amino) dodecanamide incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S) -AHPC-Me-12- ((4-Bromobutyl) amino) dodecanamide can be used in the synthesis of PROTACs, such as MS934. MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader[1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-me-12-4-bromobutyl-amino-dodecanamide.html

Smiles

CC(C)(C)[C@H](NC(CCCCCCCCCCCNCCCCBr)=O)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O

Molecular Formula

C39H62BrN5O4S

Molecular Weight

776.91

References & Citations

[1]Hu J, et al. Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders. J Med Chem. 2020 Dec 24;63 (24) :15883-15905.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Price

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