OPC-14523 (hydrochloride)
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM) . OPC-14523 hydrochloride shows antidepressant-like activity[1][2].
Product Specifications
CAS Number
145969-31-9
Product Name Alternative
BafA1
UNSPSC
12352005
Target
5-HT Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/opc-14523-hydrochloride.html
Purity
99.95
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1.[H]Cl
Molecular Formula
C23H29Cl2N3O2
Molecular Weight
450.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
Frequently Asked Questions
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