OPC-14523 (hydrochloride)

OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM) . OPC-14523 hydrochloride shows antidepressant-like activity[1][2].

Product Specifications

CAS Number

[145969-31-9]

Product Name Alternative

BafA1

UNSPSC

12352005

Target

5-HT Receptor; Sigma Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/opc-14523-hydrochloride.html

Purity

99.95

Solubility

DMSO : 83.33 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1.[H]Cl

Molecular Formula

C23H29Cl2N3O2

Molecular Weight

450.40

References & Citations

[1]Tottori K, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001;41 (8) :976-988.|[2]Bermack JE, et al. Effects of the potential antidepressant OPC-14523 [1-[3-[4- (3-chlorophenyl) -1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. J Pharmacol Exp Ther. 2004;310 (2) :578-583.