Alpha-Hydroxy farnesyl phosphonic acid
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase) . At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
Product Specifications
CAS Number
148796-53-6
Product Name Alternative
Hydroxyfarnesyl phosphate
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/alpha-hydroxy-farnesyl-phosphonic-acid.html
Smiles
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/C(P(O)(O)=O)O
Molecular Formula
C15H27O4P
Molecular Weight
302.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Gibbs, et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. Biol. Chem. 268 (11), 7617-7620 (1993) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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