4-Hydroxynonenal
4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
Product Specifications
CAS Number
75899-68-2
Product Name Alternative
4-HNE
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxynonenal.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCC(O)/C=C/C=O
Molecular Formula
C9H16O2
Molecular Weight
156.22
Precautions
H225, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH2; Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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