4-Hydroxynonenal

4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

Product Specifications

CAS Number

[75899-68-2]

Product Name Alternative

4-HNE

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxynonenal.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCC(O)/C=C/C=O

Molecular Formula

C9H16O2

Molecular Weight

156.22

Precautions

H225, H319

References & Citations

[1]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[2]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[3]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.