GNE 6901
GNE 6901 (compound 40) is a potent GluN2A-selective NMDAR positive allosteric modulator (PAM) with an EC50 of 382 nM[1].
Product Specifications
CAS Number
1698900-69-4
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gne-6901.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(S1)=C([C@H]2[C@H](CO)C2)N3C1=NC(COC4=CC=C(F)C=C4)=CC3=O
Molecular Formula
C18H17FN2O3S
Molecular Weight
360.40
References & Citations
[1]Matthew Volgraf, et al. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs) : Tuning Deactivation Kinetics via Structure-Based Design. J Med Chem. 2016 Mar 24;59 (6) :2760-79. |[2]Matthew Volgraf, et al. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs) : Tuning Deactivation Kinetics via Structure-Based Design. J Med Chem. 2016 Mar 24;59 (6) :2760-79.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
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