GNE 6901

GNE 6901 (compound 40) is a potent GluN2A-selective NMDAR positive allosteric modulator (PAM) with an EC50 of 382 nM[1].

Product Specifications

CAS Number

[1698900-69-4]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gne-6901.html

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(S1)=C([C@H]2[C@H](CO)C2)N3C1=NC(COC4=CC=C(F)C=C4)=CC3=O

Molecular Formula

C18H17FN2O3S

Molecular Weight

360.40

References & Citations

[1]Matthew Volgraf, et al. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs) : Tuning Deactivation Kinetics via Structure-Based Design. J Med Chem. 2016 Mar 24;59 (6) :2760-79. |[2]Matthew Volgraf, et al. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs) : Tuning Deactivation Kinetics via Structure-Based Design. J Med Chem. 2016 Mar 24;59 (6) :2760-79.