ELN318463

ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1) - and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1[1][2].

Product Specifications

CAS Number

[851600-86-7]

UNSPSC

12352005

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eln-318463.html

Purity

99.45

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(N(CC1=CC=C(Br)C=C1)[C@H]2C(NCCCC2)=O)(C(C=C3)=CC=C3Cl)=O

Molecular Formula

C19H20BrClN2O3S

Molecular Weight

471.80

References & Citations

[1]Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283 (5) :2927-38.|[2]Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2 (6) :36.