Apigenin

Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

Product Specifications

CAS Number

[520-36-5]

Product Name Alternative

4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Cytochrome P450; Endogenous Metabolite

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Apigenin.html

Purity

99.58

Solubility

DMSO : 80 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37 (3) :629-34.|[2]Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11 (29) :4461-4.|[3]Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.