PL-017 (TFA)
PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats[1].
Product Specifications
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pl-017-tfa.html
Solubility
H2O
Smiles
O=C(N1[C@H](CCC1)C(N)=O)[C@H](CC2=CC=CC=C2)N(C)C([C@H]3N(CCC3)C([C@@H](N)CC4=CC=C(O)C=C4)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C31H38F3N5O7
Molecular Weight
649.66
References & Citations
[1]K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227 (2) :403-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR
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