PL-017 (TFA)

PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats[1].

Product Specifications

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pl-017-tfa.html

Solubility

H2O

Smiles

O=C(N1[C@H](CCC1)C(N)=O)[C@H](CC2=CC=CC=C2)N(C)C([C@H]3N(CCC3)C([C@@H](N)CC4=CC=C(O)C=C4)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C31H38F3N5O7

Molecular Weight

649.66

References & Citations

[1]K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227 (2) :403-8.