A-1155905
A-1155905 is a MCL-1 inhibitor (IC50=33.5 nM; Ki=0.58 nM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis[1].
Product Specifications
CAS Number
2228052-37-5
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-1155905.html
Smiles
O=C(C)N(CC1)CCN1C2=CC=C(OCC3=C(C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8F)C8=CC=C7)C6=CC=C4)C(C)=NN3C)C=C2
Molecular Formula
C46H51FN6O6
Molecular Weight
802.93
References & Citations
[1]Leverson, et al. "Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) ." Cell death & disease 6.1 (2015) : e1590-e1590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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