MLS000544460
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1].
Product Specifications
CAS Number
[352336-36-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mls000544460.html
Purity
99.42
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC1=CC=CC(C(N/N=C/C2=CC=C(SC3=CC=CC=N3)O2)=O)=C1
Molecular Formula
C17H12FN3O2S
Molecular Weight
341.36
Precautions
H315, H319, H335
References & Citations
[1]Krueger AB, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cellmigration. J Biol Chem. 2014 Jun 6;289 (23) :16349-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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