L-Thyroxine (sodium)
Product Specifications
UNSPSC Description
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
Target Antigen
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/l-thyroxine-sodium.html
Purity
99.50
Solubility
0.5 M NaOH : 25 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)|DMSO : 62.5 mg/mL (ultrasonic)|H2O : 14 mg/mL (ultrasonic;adjust pH to 12 with NaOH)
Smiles
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O
Molecular Weight
798.85
References & Citations
[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.J Drug Deliv Sci Technol. 2023 Sep 28, 105008.|Cell Rep Med. 2023 May 24;101061.|Dis Model Mech. 2024 Aug 14:dmm.050748.|EMBO J. 2024 Jun 5.|Mol Brain. 2021 Jan 27;14(1):25.|Nat Immunol. 2024 Mar 18.|Sci Rep. 2022 Jul 4;12(1):11259.|Stem Cell Rev Rep. 2021 Jun;17(3):999-1013.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18341B/L-Thyroxine-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18341B/L-Thyroxine-sodium-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
55-03-8
Available Sizes
Curated Selection
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