L-Thyroxine (sodium)

L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [1].

Product Specifications

CAS Number

[55-03-8]

Product Name Alternative

Levothyroxine (sodium) ; T4 (sodium)

UNSPSC

12352005

Hazard Statement

H361, H372

Target

Endogenous Metabolite; Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/l-thyroxine-sodium.html

Concentration

10mM

Purity

99.75

Solubility

0.5 M NaOH : 25 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C) |DMSO : 62.5 mg/mL (ultrasonic) |H2O : 14 mg/mL (ultrasonic; adjust pH to 12 with NaOH)

Smiles

N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O

Molecular Formula

C15H10I4NNaO4

Molecular Weight

798.85

Precautions

H361, H372

References & Citations

[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.