PROTAC BRM/BRG1 degrader-1
PROTAC BRM/BRG1 degrader-1 (Example 253) is a PROTAC BRM/BRG1 degrader, with DC50 of 10-100 nM for BRM, > 1 μM for BRG1. PROTAC BRM/BRG1 degrader-1 can be used for cancer research. Blue: E3 ligase ligand , black: linker (HY-168244). Red: BRM/BRG1 inhibitor (HY-W539427).
Product Specifications
CAS Number
2724268-88-4
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brm-brg1-degrader-1.html
Smiles
NC(N=NC(C1=C(O)C=CC=C1)=C2)=C2OCCC3=CC=C(C(N4CC(OC5CCN(CCOC6=NOC([C@@H](C(C)C)C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=C6)CC5)C4)=O)C=C3
Molecular Formula
C54H63N9O9S
Molecular Weight
1014.20
References & Citations
[1]Matthew Netherton, et al. Compounds and uses thereof. Patent. WO2021207291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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