PROTAC BRM/BRG1 degrader-1
PROTAC BRM/BRG1 degrader-1 (Example 253) is a PROTAC BRM/BRG1 degrader, with DC50 of 10-100 nM for BRM, > 1 μM for BRG1. PROTAC BRM/BRG1 degrader-1 can be used for cancer research. Blue: E3 ligase ligand , black: linker (HY-168244). Red: BRM/BRG1 inhibitor (HY-W539427).
Product Specifications
CAS Number
2724268-88-4
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brm-brg1-degrader-1.html
Smiles
NC(N=NC(C1=C(O)C=CC=C1)=C2)=C2OCCC3=CC=C(C(N4CC(OC5CCN(CCOC6=NOC([C@@H](C(C)C)C(N7C[C@H](O)C[C@H]7C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=C6)CC5)C4)=O)C=C3
Molecular Formula
C54H63N9O9S
Molecular Weight
1014.20
References & Citations
[1]Matthew Netherton, et al. Compounds and uses thereof. Patent. WO2021207291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-D453585-25MG 25 mg
24R,25-Dihydroxy Fusidic Acid Delta-Valerolactone
Sign In for Pricing
View Details 
