KPT-276
PKT-276, an analogue of PKT-185, is an oral bioavailable and selective inhibitor of nuclear output (SINE) . PKT-276 is also a CRM1 antagonist that irreversibly binds to and blocks the function of CRM1[1].
Product Specifications
CAS Number
1421919-75-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kpt-276.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(N1CC(F)(F)C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Molecular Formula
C16H10F8N4O
Molecular Weight
426.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120 (9) :1765-73.|[2]Zhang K, et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol. 2013 Jan;41 (1) :67-78.e4.|[3]Schmidt J, et al. Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276. Leukemia. 2013 Dec;27 (12) :2357-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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