Anti-ALB, Human Serum Albumin (3B8-H3-G1) Recombinant Chicken Chimeric mAb

Human serum albumin (HSA) is the most abundant plasma protein, with a molecular weight of ~66 kDa, and plays a central role in maintaining osmotic pressure and transporting a wide range of endogenous and exogenous ligands. Structurally, HSA consists of three homologous domains, each further divided into subdomains, forming a highly flexible binding surface that accommodates fatty acids, hormones, metabolites, and therapeutic drugs. Its ligand-binding versatility contributes to critical functions in pH buffering, free radical scavenging, and drug pharmacokinetics. In addition to its transport and stabilizing roles, HSA serves as a clinical biomarker of liver function and nutritional status. Dysregulation of HSA levels is associated with pathological conditions such as liver disease, kidney dysfunction, sepsis, and cancer, underscoring its significance in both physiology and disease.

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 3B8-H3-G1 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 3B8-H3-G1 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when tested by Western Blot.