Anti-MNX1/HB9 Antibody

Our Anti-Motor Neuron and Pancreas Homeobox Protein 1 chicken polyclonal primary antibody from Aves Labs is produced in-house. It detects human, mouse, and rat MNX1, and is affinity-purified IgY. It is great for use in ICC, IHC, WB.

Product Specifications

Background

The MNX1/HB9 protein, encoded by the MNX1 gene (also known as HB9), is a transcription factor belonging to the homeobox gene family, which plays an essential role in regulating gene expression during embryonic development. MNX1/HB9 is particularly important in the spinal cord, where it drives the differentiation of motor neurons. Disruptions in MNX1 expression have been associated with developmental disorders and diseases such as spinal muscular atrophy and Currarino syndrome (Han et al 2020) . MNX1 also plays a role in certain forms of diabetes, affecting the development of insulin-producing beta cells in the pancreas (Aly et al. 2023) . Due to its influence in multiple body systems, understanding MNX1/HB9 function has potential therapeutic implications for both neurodegenerative and metabolic diseases.

Synonyms

HB9, HOXHB9, SCRA1, HLXB9, Motor Neuron And Pancreas Homeobox Protein 1, Homeobox Protein HB9

Gene Name

MNX1

UniProt

P50219

Host

Chicken

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein encompassing the C-terminal ~150 amino acids of human HB9/MNX1

Target

Motor Neuron and Pancreas Homeobox Protein 1

Clonality

Polyclonal

Isotype

IgY

Type

Primary Antibody

Applications

ICC, IHC, WB

Field of Research

Cell Markers / Neuronal Markers

Concentration

200 μg/mL

Format

Affinity-Purified IgY

Buffer

Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, " pH 7.2) with sodium azide (0.02%, w/v) added as a preservative.

Molecular Weight

40 kDa

Shipping Conditions

Ice packs

Storage Conditions

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

Notes

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification.

WB Dilution

1:200-1:1000

Specificity

No cross-reactivity reported

ICC Dilution

1:50-1:200

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.