Anti-GOLGB1 (Giantin) Antibody

GOLGB1, also known as Giantin, is a protein associated with the Golgi apparatus, playing a key role in maintaining its structural integrity and facilitating vesicle trafficking between the endoplasmic reticulum and the Golgi. Discovered within the context of Golgi apparatus research initiated by Camillo Golgi in 1898, the molecular cloning and sequencing of the GOLGB1 gene in the early 1990s allowed detailed studies of its structure and function, revealing its role in stacking Golgi cisternae and influencing various cell signaling pathways. Functional studies, including knockdown and knockout experiments (Satoh et al 2019), have demonstrated GOLGB1’s importance in maintaining Golgi integrity. A myriad of diseases are associated with Golgi dysfunction, including neurodegenerative diseases such as ALS, Alzheimer’s, and Parkinson’s, as well as cancer and congenital disorders of glycosylation (Lan etc al, 2016) . In time, GOLGB1 (Giantin) could potentially serve as a therapeutic target for many of these conditions.

Apoptosis / Cell Signaling / Neurodegenerative Disease / Alzheimer's Disease / Parkinson's Disease / Amyotrophic Lateral Sclerosis (ALS) / Oncoproteins / Vesicle Trafficking/Fusion

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.