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Anti-CSPG4/NG2 (6203-34) Recombinant Chicken Chimeric mAb

Our chicken Anti-CSPG4/NG2 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone 6203-34. It detects human, mouse, and rat CSPG4/NG2 and is purified by affinity chromatography. It works in ELISA, ICC, IHC, WB.

Product Specifications

Background

Neuron-glial antigen 2 (NG2) is a chondroitin sulfate proteoglycan that is encoded by the CSPG4 gene in humans. It is an excellent oligodendrocyte marker. NG2 is a hallmark protein of oligodendrocyte progenitor cells (OPCs) and has been linked with familial schizophrenia (de Vrij, F.M., et al, 2018) . NG2 also plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells (Luo, W., et al, 2006) . NG2 localizes at the apical plasma membrane and relocalizes to the lamellipodia of astrocytoma upon PRKCA phosphorylation.

Synonyms

Chondriotin Sulfate Proteoglycan 4, CSPG4, NG2, MSK16, MCSPG, Chondroitin Sulfate Proteoglycan NG2

Gene Name

CSPG4/NG2

UniProt

Q6UVK1

Host

Chicken

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids S1583-S2224 of human CSPG4/NG2 (accession number Q6UVK1) produced in CHO cells

Target

CSPG4/NG2

Clonality

Recombinant

Isotype

IgY

Clone

6203-34

Type

Primary Antibodies

Applications

ELISA, ICC, IHC, WB

Field of Research

Cell Markers / Glial and Schwann Cell Markers / Oligodendrocyte Markers

Concentration

1 mg/mL

Format

Purified by affinity chromatography

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

pH

7.4

Molecular Weight

250 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 6203-34 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 6203-34 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

IHC Dilution

1:100-1:250

WB Dilution

1:100-1:1000

Specificity

No cross-reactivity reported

ICC Dilution

1:100-1:250

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Brand

Aves Labs

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

WB Brain Dilution

1:100-1:1000

Conjugate

Unconjugated

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