Z-VAD (OMe) -FMK
Product Specifications
CAS Number
187389-52-2
Product Name Alternative
Caspase family inhibitor (fluoromethylketone)
Certification
RUO
Sequence
Z-Val-Ala-Asp (OMe) -fluoromethylketone
Stability
As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month.
Purity
≥95%
Solubility
Soluble in DMSO (>10mg/ml), dimethyl formamide (7mg/ml) or 100% ethanol (1.3mg/ml) .
Molecular Formula
C 22 H 30 N 3 O 7 F
Molecular Weight
467.5
Shipping Conditions
Blue Ice
Storage Conditions
-20°C
Appearance
White to off-white solid.
Applications Notes
Irreversible, cell permeable, broad spectrum caspase inhibitor. Limited Fas-induced mouse liver damage and apoptosis to <1%, at a dose of 50μmol/kg. At 50μM, abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells.
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