TNF-R1 (human) :Fc (human), (recombinant)

Product Specifications

Product Name Alternative

P55, CD120a, TNF-R 60kDa, TNFRSF 1A

Certification

RUO

UniProt

P19438

Source

Produced in HEK 293 cells. The extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1.

Stability

Stable for at least 6 months after receipt when stored at -20°C.

Concentration

1 mg/mL after reconstitution.

Purity

≥95% (SDS-PAGE)

Reconstitution

Reconstitute with 50μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.

Molecular Weight

~60kDa (reducing SDS-PAGE) .

Shipping Conditions

Blue Ice

Storage Conditions

-20°C

Notes

Previous data has shown that TNF-R1 receptor binds to TNF-R1 and triggers various biological effects (including cell death) . rhTNF-R1:Fc fusion protein blocks TNF-α-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml using Wehi cells.