Spermine NONOate

Product dissociates to the free amine and nitric oxide in a pH dependent manner following first order kinetics. Alkaline solutions of NONOates (in 0.01M NaOH) are stable and can be stored at 0°C for 24 hours. To initiate the release of nitric oxide add alkaline solution of Spermine NONOate to excess buffer of pH 7.0 – 7.4. Relatively high concentrated solutions can be prepared for further dilution. Half life in 0.1M phosphate buffer (pH 7.4) at 37 C is t1⁄2 (min.) 39. Decomposition is nearly instantaneous at pH 5.