LAG-3 (mouse) :Fc (mouse), (recombinant)
Product Specifications
Product Name Alternative
Lymphocyte activation gene-3, FDC protein, CD223
Certification
RUO
UniProt
Q61790
Source
Produced in CHO cells. The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH 2 -CH 3) .
Stability
Stable for at least 6 months after receipt when stored at -20°C.
Concentration
0.5 mg/mL
Endotoxin
<1EU/μg purified protein (LAL test; Bio Whittaker) .
Purity
≥95% (SDS-PAGE)
Activity
Induces maturation of mouse dendritic cells in vitro . Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
Reconstitution
Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Molecular Weight
~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)
Shipping Conditions
Blue Ice
Storage Conditions
-20°C
Specificity
Binds to human and mouse MHC class II.
Formulation
Liquid. In PBS.
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