KillerTRAILTM Protein (soluble) (human), (recombinant)
Product Specifications
Specifications
ED 50 : 20ng/ml (BJAB cells)
Product Name Alternative
Apo-2L, TNFSF 10, CD253
Certification
RUO
UniProt
P50591
Source
Produced in E. coli . The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
Purification
Affinity purified. Sterile filtered.
Stability
Stable for at least 12 months after receipt when stored at -80° C.
Endotoxin
≤0.01 EU/μg purified protein (LAL test) .
Purity
≥99% (SDS-PAGE, MS analysis)
Activity
Induces apoptosis in a concentration range of 10-100ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SUPERKILLERTRAIL ® (Prod. No. ALX-201-115) .
Reconstitution
For a special storage and dilution buffer see KillerTRAILTM Storage and Dilution Buffer (Prod. No. ALX-505-005) .
Molecular Weight
~24kDa (SDS-PAGE)
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Specificity
Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG) .
Formulation
Liquid. HEPES, pH 7.4, sodium chloride, Tween 20, sucrose, azide free and 1mM DTT.
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