DIGX®HPV type 16/18 probe

The HPV probe can be optimized for a polymer detection system using diluent buffer, In situ hybridization buffer for HPV probes (Ready-to-Use) (Prod. No. ENZ-33905) . DIGX ® rabbit anti-digoxigenin linker (Prod. No. ENZ-ABS303) or DIGX ® mouse anti-digoxigenin linker (Prod. No. ENZ-ABS304) can be used for the detection of the DIGX ® HPV probes in conjunction with POLYVIEW ® PLUS reagents and kits. This product or the use of this product is covered by one or more Enzo patents, including, but not limited to the following: U.S. Patent No. 4,994,373; Canadian Patent No. 1,309,672; and patents pending.

The DIGX ® HPV type 16/18 probe employs a mixture of the HPV type 16 and HPV type 18 specific probes that detect HPV types that have been associated with cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS) . The probe mixture is denatured and hybridized to the tissue section fixed and pretreated on the microscope slide. Specific hybridization between the HPV DNA probe and DNA in the specimen is determined by the detection of digoxigenin.