C-hexaAMP

Product Specifications

CAS Number

232933-63-0

Product Name Alternative

Cyclic hexaadenosine monophosphate . sodium salt, Cyclic hexaadenylate, c-A6

Certification

RUO

Stability

C-hexaAMP has sufficient stability at room temperature and does not need special care during handling or shipment. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in freeze-dried form.

Endotoxin

Has not been tested for endotoxins.

Purity

> 95% HPLC

Solubility

Soluble in water and aqueous buffers. Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.

Molecular Formula

C 60 H 72 N 30 O 36 P 6 (free acid)

Molecular Weight

1975.3 (free acid)

Shipping Conditions

Ambient Temperature

Storage Conditions

-20°C

Notes

Cyclic oligoadenylates such as c-hexaAMP were found to be novel bacterial second messengers involved in the Type 3 CRISPR-CAS associated detection and degradation of invasive genetic elements in many prokaryotes. Upon recognition and binding of invasive target RNA, the Cas10 subunit of the type 3 interference complex generates cyclic oligoadenylates which in turn act as allosteric activators of Csm6 ribonucleases taht degrade invader-derived RNA transcripts. It is suggested that the size of cyclic oligoadenylate depends on the type 3 CRISPR-CAS system present, with c-hexaAMP being prodominant signaling molecule in Enterococcus italicus and Streptococcus thermophiles (all data according to Niewoehner et al., (2017) and Kazlauskiene et al., (2017) ) .